The science of biotechnology is based mainly on two core technologies (i) Genetic engineering, which is the manipulation of genes by man. It includes techniques to alter the nature of genetic material (DNA and RNA), to introduce these into host organisms and thus, change the phenotype of the host organism (ii) Biochemical engineering, i.e., processes that help the growth of desired microbe/eukaryotic cell in large quantities in a sterile medium for the manufacture and multiplication of biotechnological product