Q. Which of the following peptide chain is removed during the maturation of proinsulin into insulin?

A) A-chain (21 amino acid)
B) B-chain (30 amino acid)
C) C-chain (33 amino acid)
D) A and B chain
Explanation

Insulin contains two short polypeptide chains, chain A and B-chain linked by disulphide bridge. In mammals, insulin is synthesised as prohormone (that needs to be processed to become mature and functional hormone). It contains an extra stretch called-peptide. C-peptide is absent in mature insulin and is removed during the maturation into insulin

Dr. Abubacker
Reviewed by Dr. Abubacker

Physics Educator & NEET/JEE Specialist

Ph.D. in Physics with 19+ years of teaching experience.