Bacillus thuringiensis froms the protein crystals, which contains a toxic insecticidal protein. Bt toxins are initially inactive protoxins but after ingestion by the insects their inactive toxin becomes active due to the alkaline pH of the gut, which solubilise the crystals. The activated toxin binds to the surface of the midgut epithelial cells thus creating pores, which causes cell swelling and lysis, further leading to death of the insect