Fertilisin antifertilisin interaction was proposed by IR Lillie. According to this theory, ovum secretes fertilisin (composed of glycoprotein = monosaccharide + Amino acid) and sperm release antifertilisin (composed of acidic amino acid). They interact with each other and they are species specific. The adhesion of sperm to the egg of the same species through chemical recognition is known as agglutination