Chromosomal mutation or change is the sudden inheritable change in the hereditary material of an organism. It caused due to the several ways like deletion, duplication, translocation, inversion, etc. Main types of Mutation Loss of Chromosome Process Loss of fragment of chromosome Inversion of fragment of chromosome Attachment of segment of one chromosome to another Repetition of a segment in a chromosome Deletion Inversion Translocatio n Duplication Gene Mutation Process Replacement of one base or more nucleotide Removal of one base or more nucleotide Addition of one base or more nucleotide Substitution Deletion Addition