Cadmium (Cd) poisoning leads to itai-itai (ouch-ouch) disease. Cadmium consumption causes diarrhea, bone deformation, kindly damage, retarded growth, CNS injury etc. Mercury (Hg) poisoning causes Minamata disease, lead (Pb) consumption cause damage to liver, heat, kidney and reduction haemoglobin formation, while black-foot disease is caused by chronic exposure to arsenic.