The Rh factor causes erythroblastosis foetalis, when a woman who is $Rh^{-}$ marries a man, who is $Rh^{+}$ , their first child will be safe (which is $Rh^{+}$) but during pregnancy some blood of foetus and mother mixes due to which the mother develops antibodies against her foetus antigen which is $Rh^{+}.$