Q. Sickle cell anaemia is
A) An autosomal linked dominant trait
B) Caused by substitution of valine by glutamic acid in the $\beta$-globin chain of haemoglobin
C) Caused by a change in base pair of DNA
D) Characterized by elongated sickle like RBCs with a nucleus
Explanation
Sickle cell anaemia is caused by a change in a single base pair of DNA. It is a genetic disease reported from Negroes. In sickle cell haemoglobin the glutamic acid in $\beta -$chain is replaced by valine. The individuals of sickle cell anaemia are immune to malaria.
Reviewed by Dr. Abubacker
Physics Educator & NEET/JEE Specialist
Ph.D. in Physics with 19+ years of teaching experience.