Mycoplasmas are the simplest and the smallest of the free living prokaryotes. Due to the absence of cell wall, the organisms can change their shape and are pleomorphic. They can survive without oxygen. Many mycoplasma are pathogenic in animals and plants. They mostly produce pleuropneumonia in domestic animals, a typical pneumonia and mycoplasmal urethritis in humans, little leaf disease of brinjal and witches broom in plants