Q. Correct order of reactivity of acid derivatives towards a nucleophile is
A) $RCOCl > (RCO)_{2}O > RCOOR > RCONH_{2}$
B) $RCOOR > RCOCl > RCONH_{2} > (RCO)_{2}O$
C) $RCONH_{2} > (RCO)_{2}O > RCOOR > RCOCl$
D) $(RCO)_{2}O > RCOCl > RCOOR > RCONH_{2}$
Explanation
(a)
The relative reactivity of the acid derivatives towards nucleophilic acyl substitution reaction follow the order :
$RCOCl > (RCO)_{2}O > RCOOR > RCONH_{2}$
The ease with which these leaving groups depart decreases in the order$:Cl^{-} > RCOO^{-} > RCO^{-} > NH_{2}^{-}$. Consequently the relative reactivities of all these acid derivatives decreases in the order : acid chloride > anhydride > ester > amide
Reviewed by Dr. Abubacker
Physics Educator & NEET/JEE Specialist
Ph.D. in Physics with 19+ years of teaching experience.