(c)
The given sigma expansion
$\sum_{m = 0}^{100}{\ ^{100}C_{m}{(x - 3)}^{100 - m}}.2^{m}$ can be written as
$\left\lbrack (x - 3) + 2 \right\rbrack^{100} = (x - 1)^{100} = (x - 1)^{100}$
$\therefore$ Coefficient of $x^{53}$ in ${(1 - x)}^{100} = {( - 1)}^{53}\ ^{100}C_{53} = - \ ^{100}C_{53}$