Q. Anaphase Promoting Complex (APC) is a protein degradation machinery necessary for proper mitosis of animal cells. If APC is defective in a human cell, which of the following is expected to occur ?
A) Chromosomes will not condense
B) Chromosomes will be fragmented
C) Chromosomes will not segregate
D) Recombination of chromosome arms will occur
Explanation
[Solution] APC degrades securin, releasing separase to cleave cohesin; without it sister chromatids cannot separate at anaphase. Answer (3).
Reviewed by Dr. Abubacker
Physics Educator & NEET/JEE Specialist
Ph.D. in Physics with 19+ years of teaching experience.