Explanation

[Solution from source] Rosie was a transgenic cow, not a buffalo, and restriction enzymes cut DNA at specific sites; isolation of DNA from other macromolecules uses enzymes such as lysozyme, cellulase, ribonuclease and protease. Downstream processing is a recognised step of recombinant DNA technology and disarmed pathogens are used as vectors, so those two statements are correct. Answer (2).