Q. Among the given compounds, the most susceptible to nucleophilic attack at the carbonyl group is
A) CH₃COCl
B) CH₃COOCH₃
C) CH₃CONH₂
D) CH₃COOCOCH₃
Explanation
[Solution from source] Acyl chlorides are the most reactive acid derivatives: Cl is strongly electron-withdrawing and gives almost no resonance donation to C=O, and Cl⁻ is an excellent leaving group. Anhydrides, esters and amides (least) are progressively less reactive. Answer (1).
Reviewed by Dr. Abubacker
Physics Educator & NEET/JEE Specialist
Ph.D. in Physics with 19+ years of teaching experience.