Q. The genetic defect – adenosine deaminase (ADA) deficiency may be cured permanently by:
A) administering adenosine deaminase activators.
B) introducing bone marrow cells producing ADA into cells at early embryonic stages.
C) enzyme replacement therapy.
D) periodic infusion of genetically engineered lymphocytes having functional ADA cDNA.
Explanation
[Solution from source] NCERT notes that if the gene from bone marrow cells producing ADA is introduced into cells at early embryonic stages, it could be a permanent cure. Infusing engineered lymphocytes is not permanent because lymphocytes are not immortal and the infusion must be repeated; enzyme replacement is also only a treatment. Answer (2).
Reviewed by Dr. Abubacker
Physics Educator & NEET/JEE Specialist
Ph.D. in Physics with 19+ years of teaching experience.