Q. Sickle cell anemia is:
A) caused by substitution of valine by glutamic acid in the beta globin chain of haemoglobin
B) caused by a change in a single base pair of DNA
C) characterized by elongated sickle like RBCs with a nucleus
D) an autosomal linked dominant trait
Explanation
[Solution from source] Sickle cell anaemia results from a single base substitution (GAG to GUG) in the β-globin gene, a point mutation, so glutamic acid at the sixth position is replaced by valine, not the other way round. The trait is autosomal recessive and mature RBCs have no nucleus. Answer (2).
Reviewed by Dr. Abubacker
Physics Educator & NEET/JEE Specialist
Ph.D. in Physics with 19+ years of teaching experience.