When oxygen is not available, yeast or some other microbes respire anaerobically. In case of anaerobic respiration, the value of respiratory quotient is not utilized, eg, $C_{6}H_{12}O_{6}$ $\overset{Zymase\ }{\rightarrow}$ 3$C_{2}H_{5}$OH + 2C$O_{2}$ + Energy Glucose Ethyl alcohol