Each enzyme [E] has a substrate [S] binding site in its molecule so that a highly reactive enzyme substrate complex [ES] is produced. This complex is short lived and dissociates into its product and the unchanged enzyme with an intermediate formation of the enzyme product complex [EP] The formation of the ES complex is essential for catalysis $E + S \rightleftharpoons Es \longrightarrow E - P \longrightarrow E + P$