All of these. Osmoreceptors in the body are activated by changes in the blood volume, body fluid volume and ionic concentration. An excessive loss of fluid from the body can activate these receptors, which stimulate the hypothalamus to release ADH (Antidiuretic Hormone) or vasopressin from neurohypophysis (posterior lobe of pituitary). ADH facilitate the water reabsorption from latter parts of the tubule there by preventing decreases or water loss