Explanation

Hypersecretion of growth hormone (GH) or somatotrophin hormone (STH) from adenohypophysis or anterior lobe of pituitary gland causes gigantism in children and acromegaly in adulthood. Gigantism involves excessive growth (lengthening) of bones with enlargement of internal organs as well. Acromegaly causes abnormal thickening of bones (due to ossification of periosteum) especially at face and margins of hand and feet.