Myxoedema (Gull’s disease) occurs due to the deficiency of throxine in adults. It causes low BMR (by 30-40%). Low body temperature, tendency to retain water in tissues, reduced heart rate, pulse rate, blood pressure and cardiac output, low sugar and iodine level in blood, muscular weakness and oedema (accumulation of interstitial fluid that causes the facial tissues to swell and look fluffy).