Myxoedema (gull’s disease) occurs due to deficiency of thyroxine in adults. It is characterised by (i) Low BMR (30-40%) (ii) Low body temperature (iii) Tendency to retain water (iv) Reduced heart rate/pulse rate (v) Low sugar and iodine level in blood, muscular weakness (vi) Oedema (accumulation of interstitial fluid that causes the facial tissue to swell and look fluffy)