Explanation

At high concentration (greater than physiologic) glucocorticoids (such as hydrocortisol or prednisone) are useful for treatment or allergies and inflammation. Hence they have anti-inflammatory effects. Glucocorticoids induce the synthesis of lipocortin, an inhibitor of phospholipase $A_{2}$ (Phospholipase $A_{2}$ is the enzyme that liberates arachidonate from membrane phospholipids, providing the precursor for prostaglanding and leukotriene synthesis). Since prostaglandins and leukotrienes are involved in the inflammatory response, glucocorticoids have anti-inflammatory properties by inhibiting formation of the precursor (arachidonate)